|
KMID : 0369820120420020101
|
|
Jorunal of Korean Pharmaceutical Sciences
2012 Volume.42 No. 2 p.101 ~ p.108
|
|
|
Drug stabilization and controlled release from AB3 type tetra block copolymer based polymersome
|
|
Jeong Doo-Yong
Seo Seog-Jin
Na Kun
|
|
|
Abstract
|
|
|
|
In order to increase the bioavailability of hydrophilic unstable drugs, polymersomes from AB3 type tetra block copolymers composing of poly(ethylene glycol)-b-(3) poly(lactic acid) (EO-3LA) as a water-soluble drug delivery carrier have been investigated due to its unique properties such as high stability and high water soluble drug loading efficiency. The sizes of EO-3LA polymersomes determined by dynamic light scattering were ranged in 190?220 nm with monodispersion. Its polymeric layer with 10?20 nm at the outershell was observed by field emission scanning electron microscopy. The polymersomes showed low critical aggregation concentrations (9.2?14.9 ug/ml). Anthocyanin was employed as a model drug for unstable drug in this study. The anthocyanin loading contents of EO-3LA polymersomes are depending on PLLA content in the polymers. The high loading contents (6.6?7.0 wt%) of the polymersomes are due to their tight and rigid polymeric membranes. The polymeric membrane in EO-3LA polymersomes contributed to improve drug stability on various pHs. Moreover, this property induced sustained anthocyanin release pattern from the polymersome. Therefore, the polymersome has potential as a drug carrier for water-soluble and unstable drugs.
|
|
|
KEYWORD
|
|
|
Polymersomes, AB3 type tetra block, Anthocyanin, Polymeric membranes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|